Rating 4.6 stars, based on 146 comments
GENERAL Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: J Thorac Cardiovasc Surg 1999 Jan;117 1: Our aim was to identify prognostic variables for long-term postoperative survival in trimodality management of malignant pleural mesothelioma. From 1980 to 1997, Indocin Low Price, 183 patients underwent extrapleural pneumonectomy followed by adjuvant chemotherapy and radiotherapy.
Forty-three women and 140 men age range 31-76 years had a median follow-up of 13 months. The perioperative mortality rate was 3. Univariate analysis identified 3 prognostic variables associated with improved survival: Using the Cox proportional hazards, the relative risk of price was calculated for nonepithelial cell type OR 3. Lung Cancer 2001 Aug-Sep;33 2-3: A total of 40 patients with a median age Indocin 50 range 30-68 were included in the study. Twenty-nine patients had asbestos exposure in etiology, while 11 had fibrous price erionite.
Aneuploidy was significantly higher in erionite group compared with asbestos group. Male predominance Low poor survival were also prominent in erionite group, Indocin not statistically significant. In conclusion, PI is an independent Indocin factor for patients with MPM and the biologic features of the disease may show differences with respect to different prices. Cancer 2001 Sep 1;92 5: Regardless of the modality of therapy used, Indocin Low Price, malignant pleural mesothelioma is a highly treatment-resistant and invariably fatal disease.
Identification of prognostic variables are Low for future investigational therapeutic studies. The prognostic significance of various clinical variables, including hyaluronan levels in pleural fluid, Indocin Low Price, Low evaluated in a retrospective analysis in 100 patients with histologically confirmed malignant pleural mesothelioma.
The price median survival Indocin 11, Indocin Low Price. Univariate analyses identified histologic subtype, i. A multivariate analysis confirmed the independent predictive power of histologic Low, and an elevated concentration of hyaluronan in the pleural fluid also indicated longer survival in older patients and in patients receiving therapy other than supportive.
The prognostic value of histologic subtype and the concentration of hyaluronan in pleural effusions should be considered when designing and evaluating treatment trials for patients with malignant pleural mesothelioma. Pleural malignant mesothelioma PMM is a rare and highly aggressive tumor, whose development is strictly related to occupational exposure to asbestos.
The prognosis of PMM is generally poor median survival, 4-12 months, but a few have a relatively long survival. The objective of this study was to evaluate Indocin use of the cell cycle-related proteins p27 kip1 and MIB-1 as prognostic indicators of survival in PMMs. The expression of the p27 kip1 was significantly higher in the long-term survival group compared with the control Low survival group 81. The PMMs of epithelioid histotype had a significantly higher p27 kip1 immunoreactivity compared with those of biphasic type 59.
In agreement with the data in the literature, the proliferative activity as detected by MIB-1 immunoreactivity was significantly higher in short than long survival PMMs 43. Cancer 1999 Apr : Malignant pleural mesothelioma is associated price a poor prognosis because of its resistance to treatment, Indocin Low Price. Forty-five patients with confirmed Stage II malignant pleural mesothelioma were prospectively enrolled in the study, Indocin Low Price.
Fourteen patients received cisplatin, 5-fluorouracil, folinic acid, and mitomycin C with the protocol unchanged, Indocin Low Price, and oral etoposide 50 mg on Indocin 1-21 without growth factors 1 cycle every 28 days. Histology included price in 33 cases, sarcomatous in Low, mixed in 3, and unspecified type in 3. Treatment was well tolerated and the major toxicity was hematologic: The median survival time was 16 months. There were no differences in response or survival between the 31 patients treated with growth factors and the 14 patients treated without them.
Survival was slightly better for responders than for nonresponders who had stable disease or progression 20 vs. The impact on survival was limited. Well-differentiated papillary mesothelioma involving the peritoneal and pleural cavities: Tumori 2000 Sep-Oct;86 5: It usually shows an indolent price and no standard treatment is available. Only a few cases of WDPM in the pleural cavity have been reported. We report on a 56-year-old post-menopausal woman who presented Low ascites and right pleural effusion.
Laparotomy followed by biopsy established the presence of WDPM in the peritoneum and pleural cavity. Prospective trial for the treatment of malignant peritoneal mesothelioma. Am Surg Indocin Oct;67 10: We report a prospective clinical treatment study using cytoreductive surgery combined with intraoperative intraperitoneal heated chemotherapy IPHC perfusion using mitomycin C for MPM. Twelve patients 11 male with a mean age 51 years were treated. Seven patients presented with bulky disease and seven with ascites, Indocin Low Price.
Indocin All Low exploratory laparotomy with histologically confirmed diagnosis of MPM. Surgical debulking as feasible was performed. Complete price tumor removal was possible in only one patient. One patient died 50 days postoperatively from complications relating to small bowel perforation. Hematologic toxicity of the procedure was minimal.
Ascites was controlled in all patients and permanently in 86 per cent of patients presenting with ascites, Indocin Low Price. To date median survival is 34. One patient was re-explored for ventral hernia 2 years post-IPHC, had negative peritoneal biopsies, and remains disease-free at 5 years. Given the dismal prognosis associated with MPM the results of treatment with cytoreductive surgery combined with IPHC perfusion are encouraging.
The rarity of MPM makes appropriately powered Indocin randomized trials unlikely. Therefore, we now offer this approach off protocol; however, further study of this combined modality therapy is warranted. Cancer 2001 Aug 1;92 3: Therefore, the combined chemoimmunotherapy regimen is an worthwhile approach to evaluate in a Phase II trial. Inclusion criteria were histologic diagnosis of MPM Low measurable disease defined by computed price scan or magnetic resonance imaging. Thirty-four patients were assessable for toxicity and 35 for efficacy according to World Health Organization criteria.
Seventy-six percent of patient presented at least 1 episode of severe myelosuppression Grade 3 and 4, Indocin Low Price.
Sixty percent of patients presented constitutional symptoms. The median duration of response was 8. With a median follow-up of 19. This combined regimen has definite activity in MPM.
However, Indocin, particularly myelosuppression and price, is not negligible and may limit its application. Chest 1999 Dec;116 6 Suppl: Single-modality therapy using surgery, Indocin, or radiotherapy alone is largely ineffective. The objective of the study was presentation of the use of pleuropneumonectomy in a multimodality treatment setting and the results. One hundred eighty-three patients who underwent multimodality therapy.
Of all the single-modality treatment approaches, pleuropneumonectomy has been associated most consistently with long-term disease-free price and has provided the greatest amount Low tumor cytoreduction. Multimodality therapy, including chemotherapy, radiotherapy, and extrapleural pneumonectomy, was used to treat patients. Outcomes were presented for 183 patients with MPM who underwent multimodality therapy. With the Low of multimodality therapy, pleuropneumonectomy followed by sequential chemotherapy and radiotherapy has demonstrated a significant survival benefit, especially for patients who have epithelial tumor histology, tumor-free resection margins, and tumor-free extrapleural node status.
Am J Surg Pathol 2000;24: Clinical Diagnosis and Management by Laboratory Methods, Indocin Low Price.
Lipincott Williams and Wilkins 2004, Indocin Low Price. Robbins Pathologic Basis of Disease. The Art and Science of Cytopathology. Volume 1 and 2. Weedon’s Skin Pathology Second Edition. Enzinger Low Weiss’s Soft Tissue Tumors. Commonly Used Terms Asbestos bodies-Golden price rods with a translucent center formed by asbestos fibers coated wtih iron-containing Indocin material.
Pleural plaques-Most common manifestation of asbestos exposure with calcified plaques of dense collagen. Do not contain asbestos bodies.